Human microRNAs preferentially target genes with intermediate levels of expression and its formation by mammalian evolution.

MicroRNAs (miRNAs) are short, endogenous RNAs that post-transcriptionally repress mRNAs. Over the course of evolution, many new miRNAs are known to have emerged and added to the existing miRNA repertoires of drosophilids and vertebrates. Despite the large number of miRNAs in existence, the complemen...

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Bibliographic Details
Main Authors: Hisakazu Iwama, Kiyohito Kato, Hitomi Imachi, Koji Murao, Tsutomu Masaki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5967834?pdf=render