Implications of the hybrid epithelial/mesenchymal phenotype in metastasis

Implications of the hybrid epithelial/mesenchymal phenotype in metastasis

Understanding cell-fate decisions during tumorigenesis and metastasis is a major challenge in modern cancer biology. One canonical cell-fate decision that cancer cells undergo is Epithelial-to-Mesenchymal Transition (EMT) and its reverse Mesenchymal-to-Epithelial Transition (MET). While transitionin...

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Bibliographic Details
Main Authors: Mohit Kumar eJolly, Marcelo eBoareto, Bin eHuang, Dongya eJia, Mingyang eLu, José N Onuchic, Herbert eLevine, Eshel eBen-Jacob
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Oncology
Subjects:
cancer systems biology
cancer stem cells (CSC)
partial EMT
Intermediate EMT
Cell-fate decisions
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00155/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00155/full

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