Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.

Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis.

The use of human pluripotent cell progeny for cardiac disease modeling, drug testing and therapeutics requires the ability to efficiently induce pluripotent cells into the cardiomyogenic lineage. Although direct activation of the Activin-A and/or Bmp pathways with growth factors yields context-depen...

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Bibliographic Details
Main Authors: Min-Su Kim, Audrey Horst, Steven Blinka, Karl Stamm, Donna Mahnke, James Schuman, Rebekah Gundry, Aoy Tomita-Mitchell, John Lough
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4338295?pdf=render

Internet

http://europepmc.org/articles/PMC4338295?pdf=render

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