Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

Background: Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT). The DAT is a membrane protein that controls DA homeostasis through the hi...

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Bibliographic Details
Main Authors: Etienne Cartier, Peter J. Hamilton, Andrea N. Belovich, Aparna Shekar, Nicholas G. Campbell, Christine Saunders, Thorvald F. Andreassen, Ulrik Gether, Jeremy Veenstra-Vanderweele, James S. Sutcliffe, Paula G. Ulery-Reynolds, Kevin Erreger, Heinrich J.G. Matthies, Aurelio Galli
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:EBioMedicine
Subjects:
Autism spectrum disorder
Dopamine
Transporter
Drosophila
Syntaxin 1
Casein kinase 2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396415000304

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http://www.sciencedirect.com/science/article/pii/S2352396415000304

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