Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors

Longitudinal immunosequencing in healthy people reveals persistent T cell receptors rich in highly public receptors

Abstract Background The adaptive immune system maintains a diversity of T cells capable of recognizing a broad array of antigens. Each T cell’s specificity for antigens is determined by its T cell receptors (TCRs), which together across all T cells form a repertoire of millions of unique receptors i...

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Bibliographic Details
Main Authors: Nathaniel D. Chu, Haixin Sarah Bi, Ryan O. Emerson, Anna M. Sherwood, Michael E. Birnbaum, Harlan S. Robins, Eric J. Alm
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Immunology
Subjects:
T cell receptor
Persistent receptors
Immunosequencing
Repertoire sequencing
Healthy controls
Memory T cell
Online Access:http://link.springer.com/article/10.1186/s12865-019-0300-5

Internet

http://link.springer.com/article/10.1186/s12865-019-0300-5

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