Impaired functions of macrophage from cystic fibrosis patients: CD11b, TLR-5 decrease and sCD14, inflammatory cytokines increase.

Impaired functions of macrophage from cystic fibrosis patients: CD11b, TLR-5 decrease and sCD14, inflammatory cytokines increase.

BACKGROUND: Early in life, cystic fibrosis (CF) patients are infected with microorganisms. The role of macrophages has largely been underestimated in literature, whereas the focus being mostly on neutrophils and epithelial cells. Macrophages may however play a significant role in the initiating stag...

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Bibliographic Details
Main Authors: Karin Simonin-Le Jeune, André Le Jeune, Stéphane Jouneau, Chantal Belleguic, Pierre-François Roux, Marie Jaguin, Marie-Thérèse Dimanche-Boitre, Valérie Lecureur, Caroline Leclercq, Benoît Desrues, Graziella Brinchault, Jean-Pierre Gangneux, Corinne Martin-Chouly
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3787056?pdf=render

Internet

http://europepmc.org/articles/PMC3787056?pdf=render

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