Reactive oxygen species that activate c-Abl signaling trigger motoneuron death in non-cell-autonomous models of ALS

Reactive oxygen species that activate c-Abl signaling trigger motoneuron death in non-cell-autonomous models of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which pathogenesis and death of motor neurons are triggered by non-cell-autonomous mechanisms. We showed earlier that exposing primary rat spinal cord cultures to conditioned media derived from primary mouse astrocytes (ACM)...

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Bibliographic Details
Main Authors: Fabiola eRojas, David Andrés González Figueroa, Nicole eCortés Almuna, Estibaliz eAmpuero, Diego eHernandez, Elsa eFritz, Sebastian eAbarzua, Alexis eMartinez, Alvaro A Elorza, Alejandra eAlvarez, Felipe eCourt, Brigitte evan Zundert
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Mitochondria
motor neuron
ALS
reactive oxygen species (ROS)
non-cell-autonomous
c-Abl.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00203/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00203/full

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