Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways

Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways

Crocetin and crocin are two important carotenoids isolated from saffron (Crocus sativus L.), which have been used as natural biomedicines with beneficial effects for improving the suboptimal health status associated with abnormal angiogenesis. However, the anti-angiogenic effects and underlying mech...

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Bibliographic Details
Main Authors: Chen Zhao, Hio-Tong Kam, Yan Chen, Guiyi Gong, Maggie Pui-Man Hoi, Krystyna Skalicka-Woźniak, Alberto Carlos Pires Dias, Simon Ming-Yuen Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
crocetin
crocin
angiogenesis
VEGF
zebrafish
HUVEC
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.675359/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.675359/full

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