IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis

IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis

Moderate-intensity exercise can help delay the development of osteoarthritis (OA). Previous studies have shown that the purinergic receptor P2X ligand gated ion channel 7 (P2X7) is involved in OA development and progression. To investigate the effect of exercise on P2X7 activation and downstream sig...

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Bibliographic Details
Main Authors:	Zihao Li, Ziyu Huang, He Zhang, Jinghan Lu, Yingliang Wei, Yue Yang, Lunhao Bai
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	P2X7 receptor autophagy endoplasmic reticulum stress protein kinase R-like endoplasmic reticulum kinase inositol-requiring enzyme-1 mammalian target of rapamycin
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.695041/full

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