IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis

IRE1-mTOR-PERK Axis Coordinates Autophagy and ER Stress-Apoptosis Induced by P2X7-Mediated Ca2+ Influx in Osteoarthritis

Moderate-intensity exercise can help delay the development of osteoarthritis (OA). Previous studies have shown that the purinergic receptor P2X ligand gated ion channel 7 (P2X7) is involved in OA development and progression. To investigate the effect of exercise on P2X7 activation and downstream sig...

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Bibliographic Details
Main Authors: Zihao Li, Ziyu Huang, He Zhang, Jinghan Lu, Yingliang Wei, Yue Yang, Lunhao Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
P2X7 receptor
autophagy
endoplasmic reticulum stress
protein kinase R-like endoplasmic reticulum kinase
inositol-requiring enzyme-1
mammalian target of rapamycin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.695041/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.695041/full

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