Therapeutic efficacy of intra-articular delivery of encapsulated human mesenchymal stem cells on early stage osteoarthritis

Therapeutic efficacy of intra-articular delivery of encapsulated human mesenchymal stem cells on early stage osteoarthritis

Mesenchymal stem cells (MSCs) represent a great therapeutic promise in pre-clinical models of osteoarthritis (OA), but many questions remain as to their therapeutic mechanism of action: engraftment versus paracrine action. Encapsulation of human MSCs (hMSCs) in sodium alginate microspheres allowed f...

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Bibliographic Details
Main Authors: JM McKinney, TN Doan, L Wang, J Deppen, DS Reece, KA Pucha, S Ginn, RD Levit, NJ Willett
Format: Article
Language:English
Published: AO Research Institute Davos 2019-01-01
Series:European Cells & Materials
Subjects:
Osteoarthritis
medial meniscal transection
human mesenchymal stem cells
cellular encapsulation
osteophytes
paracrine signaling
contrast enhanced micro-computed tomography.
Online Access:http://www.ecmjournal.org/papers/vol037/pdf/v037a04.pdf

Internet

http://www.ecmjournal.org/papers/vol037/pdf/v037a04.pdf

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