Specific functions of Exostosin-like 3 (EXTL3) gene products

Abstract Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix. A lack of EXTL3 reduces HS lev...

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Bibliographic Details
Main Author: Shuhei Yamada
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
Online Access:http://link.springer.com/article/10.1186/s11658-020-00231-y