Icariin Ameliorates Diabetic Renal Tubulointerstitial Fibrosis by Restoring Autophagy via Regulation of the miR-192-5p/GLP-1R Pathway

Icariin Ameliorates Diabetic Renal Tubulointerstitial Fibrosis by Restoring Autophagy via Regulation of the miR-192-5p/GLP-1R Pathway

Tubulointerstitial fibrosis is one of the most common pathological features of diabetic nephropathy. Autophagy, an intracellular mechanism to remove damaged or dysfunctional cell parts and maintain metabolic homeostasis, is inhibited in diabetic neuropathy. Icariin is a traditional Chinese medicine...

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Bibliographic Details
Main Authors: Zhirong Jia, Kaiwei Wang, Yameng Zhang, Yalei Duan, Kang Xiao, Shuo Liu, Xuansheng Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
diabetic kidney disease
diabetic tubulointerstitial fibrosis
autophagy
icariin
testosterone
miR-192-5p
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.720387/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.720387/full

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