Analyses and comparison of accuracy of different genotype imputation methods.

The power of genetic association analyses is often compromised by missing genotypic data which contributes to lack of significant findings, e.g., in in silico replication studies. One solution is to impute untyped SNPs from typed flanking markers, based on known linkage disequilibrium (LD) relations...

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Bibliographic Details
Main Authors: Yu-Fang Pei, Jian Li, Lei Zhang, Christopher J Papasian, Hong-Wen Deng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2569208?pdf=render