Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

Purine Nucleotide Availability Regulates mTORC1 Activity through the Rheb GTPase

Pharmacologic agents that interfere with nucleotide metabolism constitute an important class of anticancer agents. Recent studies have demonstrated that mTOR complex 1 (mTORC1) inhibitors suppress de novo biosynthesis of pyrimidine and purine nucleotides. Here, we demonstrate that mTORC1 itself is s...

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Bibliographic Details
Main Authors: Natasha Emmanuel, Shoba Ragunathan, Qin Shan, Fang Wang, Andreas Giannakou, Nanni Huser, Guixian Jin, Jeremy Myers, Robert T. Abraham, Keziban Unsal-Kacmaz
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
mTORC1
GARFT
GART
purine biosynthesis
GTP
ATP
Rheb
farnesylation
AG2037
pemetrexed
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471730685X

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http://www.sciencedirect.com/science/article/pii/S221112471730685X

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