Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting

Abstract Background The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldwide. Since cells alter their metabolic rewiring during tumorigenesis an...

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Bibliographic Details
Main Authors: Beatrice Parma, Vignesh Ramesh, Paradesi Naidu Gollavilli, Aarif Siddiqui, Luisa Pinna, Annemarie Schwab, Sabine Marschall, Shuman Zhang, Christian Pilarsky, Francesca Napoli, Marco Volante, Sophia Urbanczyk, Dirk Mielenz, Henrik Daa Schrøder, Marc Stemmler, Heiko Wurdak, Paolo Ceppi
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Non-small cell lung cancer
Metabolism
HSPD1
Targeting
KHS101
Online Access:https://doi.org/10.1186/s13046-021-02049-8

Internet

https://doi.org/10.1186/s13046-021-02049-8

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