Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids

Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids

Abstract Background The first step in SARS-CoV-2 infection is binding of the virus to angiotensin converting enzyme 2 (ACE2) on the airway epithelium. Asthma affects over 300 million people world-wide, many of whom may encounter SARS-CoV-2. Epidemiologic data suggests that asthmatics who get infecte...

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Bibliographic Details
Main Authors: Sarah L. O’Beirne, Jacqueline Salit, Robert J. Kaner, Ronald G. Crystal, Yael Strulovici-Barel
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Respiratory Research
Subjects:
Asthma
Maintenance inhaled corticosteroids
ACE2
SARS-CoV-2
Gene expression
Large airway epithelium
Online Access:https://doi.org/10.1186/s12931-021-01782-0

Internet

https://doi.org/10.1186/s12931-021-01782-0

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