A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells

A transcriptomic analysis of serial-cultured, tonsil-derived mesenchymal stem cells reveals decreased integrin α3 protein as a potential biomarker of senescent cells

Abstract Background Mesenchymal stem cells (MSCs) have been widely used for stem cell therapy, and serial passage of stem cells is often required to obtain sufficient cell numbers for practical applications in regenerative medicine. A long-term serial cell expansion can potentially induce replicativ...

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Bibliographic Details
Main Authors: Da Hyeon Choi, Se-Young Oh, Ju Kwang Choi, Kyeong Eun Lee, Ju Yeon Lee, Yoon Jeong Park, Inho Jo, Yoon Shin Park
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Stem Cell Research & Therapy
Subjects:
AKT
Culture-aged
ECM-receptor protein
Integrin α3
Senescence
Serial passaging
Online Access:http://link.springer.com/article/10.1186/s13287-020-01860-y

Internet

http://link.springer.com/article/10.1186/s13287-020-01860-y

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