Impact of extracellular matrix stiffness on genomic heterogeneity in MYCN-amplified neuroblastoma cell line

Impact of extracellular matrix stiffness on genomic heterogeneity in MYCN-amplified neuroblastoma cell line

Abstract Background Increased tissue stiffness is a common feature of malignant solid tumors, often associated with metastasis and poor patient outcomes. Vitronectin, as an extracellular matrix anchorage glycoprotein related to a stiff matrix, is present in a particularly increased quantity and spec...

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Bibliographic Details
Main Authors: Amparo López-Carrasco, Susana Martín-Vañó, Rebeca Burgos-Panadero, Ezequiel Monferrer, Ana P. Berbegall, Beatriz Fernández-Blanco, Samuel Navarro, Rosa Noguera
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Biotensegrity
Clonal selection
Stiffness
Vitronectin
Xenograft
3D-bioprinting
Online Access:http://link.springer.com/article/10.1186/s13046-020-01729-1

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http://link.springer.com/article/10.1186/s13046-020-01729-1

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