Mutations in Liver X Receptor Alpha that Impair Dimerization and Ligand Dependent Transactivation

Mutations in Liver X Receptor Alpha that Impair Dimerization and Ligand Dependent Transactivation

Liver X receptor alpha (LXRα) is crucial for the maintenance of lipid and cholesterol homeostasis. Ligand binding and dimerization with retinoid X receptor (RXR) or peroxisome proliferator-activated receptor (PPAR) is required for forming active DNA binding complexes leading to gene regulation. Stru...

Full description

Bibliographic Details
Main Authors: Shimpi Bedi, Heather A. Hostetler, Stanley Dean Rider, Jr.
Format: Article
Language:English
Published: KenzPub 2017-08-01
Series:Nuclear Receptor Research
Subjects:
Liver X receptor alpha
peroxisome proliferator-activated receptor alpha
retinoid X receptor alpha
Sterol Regulatory Element Binding Protein-1c
Apolipoprotein A119
Online Access:http://www.kenzpub.com/journals/nurr/2017/101302/

Internet

http://www.kenzpub.com/journals/nurr/2017/101302/

Similar Items