Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials

Development of an objective gene expression panel as an alternative to self-reported symptom scores in human influenza challenge trials

Abstract Background Influenza challenge trials are important for vaccine efficacy testing. Currently, disease severity is determined by self-reported scores to a list of symptoms which can be highly subjective. A more objective measure would allow for improved data analysis. Methods Twenty-one volun...

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Bibliographic Details
Main Authors: Julius Muller, Eneida Parizotto, Richard Antrobus, James Francis, Campbell Bunce, Amanda Stranks, Marshall Nichols, Micah McClain, Adrian V. S. Hill, Adaikalavan Ramasamy, Sarah C. Gilbert
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Translational Medicine
Subjects:
Influenza
Challenge trial
Symptom scores
Biomarker
Transcriptomics
Online Access:http://link.springer.com/article/10.1186/s12967-017-1235-3

Internet

http://link.springer.com/article/10.1186/s12967-017-1235-3

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