Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity

Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity

Type 2 diabetes increases the risk for dementia, including Alzheimer’s disease (AD). Pioglitazone (Pio), a pharmacological agonist of the peroxisome proliferator-activated receptor γ (PPARγ), improves insulin sensitivity and has been suggested to have potential in the management of AD symptoms, albe...

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Bibliographic Details
Main Authors: Susanne Moosecker, Patrícia Gomes, Chrysoula Dioli, Shuang Yu, Ioannis Sotiropoulos, Osborne F. X. Almeida
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Alzheimer’s disease
amyloid beta
pioglitazone
PPARγ
neurons
Tau missorting
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00239/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00239/full

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