Exovesicular-Shh confers Imatinib resistance by upregulating Bcl2 expression in chronic myeloid leukemia with variant chromosomes

Exovesicular-Shh confers Imatinib resistance by upregulating Bcl2 expression in chronic myeloid leukemia with variant chromosomes

Abstract Chronic myeloid leukemia (CML) patients with complex chromosomal translocations as well as non-compliant CML patients often demonstrate short-lived responses and poor outcomes on the current therapeutic regimes using Imatinib and its variants. It has been derived so far that leukemic stem c...

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Bibliographic Details
Main Authors: Anusha, Hamza Dalal, Sitalakshmi Subramanian, Snijesh V. P., Divya A. Gowda, Krishnamurthy H., Sharat Damodar, Neha Vyas
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03542-w

Internet

https://doi.org/10.1038/s41419-021-03542-w

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