Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons

Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (G4-DNA) structures. G4-DNA regulates replication and transcription, at least in cancer cells. Here, we demonstrate that, in neurons, pharmacologically stabilizing G4-DNA with G4 ligands strongly downregulates the Atg7 gene. Atg7 is...

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Bibliographic Details
Main Authors: Jose F Moruno-Manchon, Pauline Lejault, Yaoxuan Wang, Brenna McCauley, Pedram Honarpisheh, Diego A Morales Scheihing, Shivani Singh, Weiwei Dang, Nayun Kim, Akihiko Urayama, Liang Zhu, David Monchaud, Louise D McCullough, Andrey S Tsvetkov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
autophagy
G-quadruplex
aging
neurodegeneration
neurons
Online Access:https://elifesciences.org/articles/52283

Internet

https://elifesciences.org/articles/52283

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