A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors

A human PET study of [11C]HMS011, a potential radioligand for AMPA receptors

Abstract Background α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor is a primary mediator of fast glutamatergic excitatory signaling in the brain and has been implicated in diverse neuropsychiatric diseases. We recently developed a novel positron emission tomography (PET) ligand, 2...

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Bibliographic Details
Main Authors: Keisuke Takahata, Yasuyuki Kimura, Chie Seki, Masaki Tokunaga, Masanori Ichise, Kazunori Kawamura, Maiko Ono, Soichiro Kitamura, Manabu Kubota, Sho Moriguchi, Tatsuya Ishii, Yuhei Takado, Fumitoshi Niwa, Hironobu Endo, Tomohisa Nagashima, Yoko Ikoma, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
Format: Article
Language:English
Published: SpringerOpen 2017-08-01
Series:EJNMMI Research
Subjects:
PET
Perampanel
AMPA
[11C]HMS011
Interspecies differences
Online Access:http://link.springer.com/article/10.1186/s13550-017-0313-0

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http://link.springer.com/article/10.1186/s13550-017-0313-0

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