TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease

TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease

Summary: Neurodegenerative diseases are characterized by the formation and propagation of protein aggregates, especially amyloid fibrils. However, what normally suppresses protein misfolding and aggregation in metazoan cells remains incompletely understood. Here, we show that TRIM11, a member of the...

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Bibliographic Details
Main Authors: Guixin Zhu, Dilshan S. Harischandra, Shivani Ghaisas, Pengfei Zhang, Wil Prall, Liangqian Huang, Chantal Maghames, Lili Guo, Esteban Luna, Korrie L. Mack, Mariana P. Torrente, Kelvin C. Luk, James Shorter, Xiaolu Yang
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Cell Reports
Subjects:
TRIM proteins
TRIM11
protein quality control
molecular chaperone
disaggregase
SUMO E3 ligase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720314078

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http://www.sciencedirect.com/science/article/pii/S2211124720314078

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