Design of Linear and Cyclic Mutant Analogues of Dirucotide Peptide (MBP<sub>82–98</sub>) against Multiple Sclerosis: Conformational and Binding Studies to MHC Class II

Design of Linear and Cyclic Mutant Analogues of Dirucotide Peptide (MBP<sub>82–98</sub>) against Multiple Sclerosis: Conformational and Binding Studies to MHC Class II

Background: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system. MS is a T cell-mediated disease characterized by the proliferation, infiltration, and attack of the myelin sheath by immune cells. Previous studies have shown that cyclization provides molecules with strict...

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Bibliographic Details
Main Authors: George Deraos, Eftichia Kritsi, Minos-Timotheos Matsoukas, Konstantina Christopoulou, Hubert Kalbacher, Panagiotis Zoumpoulakis, Vasso Apostolopoulos, John Matsoukas
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Brain Sciences
Subjects:
multiple sclerosis
MS
cyclic peptide
MBP
dirucotide
HLA-DR2
HLA-DR4
myelin basic protein
altered peptide ligand
Online Access:https://www.mdpi.com/2076-3425/8/12/213

Internet

https://www.mdpi.com/2076-3425/8/12/213

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