XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability.

XRN1 stalling in the 5' UTR of Hepatitis C virus and Bovine Viral Diarrhea virus is associated with dysregulated host mRNA stability.

We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV) contain regions in their 5' UTRs that stall and repress the enzymatic activity of the cellular 5'-3' exoribonuclease XRN1, resulting in dramatic changes in the stability of cellular mRNAs. We used...

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Bibliographic Details
Main Authors: Stephanie L Moon, Jeffrey G Blackinton, John R Anderson, Mary K Dozier, Benjamin J T Dodd, Jack D Keene, Carol J Wilusz, Shelton S Bradrick, Jeffrey Wilusz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4352041?pdf=render

Internet

http://europepmc.org/articles/PMC4352041?pdf=render

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