Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice

Notch Dosage: Jagged1 Haploinsufficiency Is Associated With Reduced Neuronal Division and Disruption of Periglomerular Interneurons in Mice

Neural stem cells in the lateral ganglionic eminence (LGE) generate progenitors that migrate through the rostral migratory stream (RMS) to repopulate olfactory bulb (OB) interneurons, but the regulation of this process is poorly defined. The evolutionarily conserved Notch pathway is essential for ne...

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Bibliographic Details
Main Authors: Christopher A. Blackwood, Alessandro Bailetti, Sayan Nandi, Thomas Gridley, Jean M. Hébert
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Notch
neurogenesis
olfactory bulb
interneurons
lateral ganglionic eminence
Alagille syndrome
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00113/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00113/full

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