Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: Mechanistic relationship and differential sensitivity to intervention

Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: Mechanistic relationship and differential sensitivity to intervention

The combination of Ca2+ influx during neurotransmission and low cytosolic Ca2+ buffering contributes to the preferential vulnerability of motor neurons in amyotrophic lateral sclerosis (ALS). This study investigated the relationship among Ca2+ accumulation in intracellular compartments, mitochondria...

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Bibliographic Details
Main Authors: Miranda L. Tradewell, Laura A. Cooper, Sandra Minotti, Heather D. Durham
Format: Article
Language:English
Published: Elsevier 2011-06-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis (ALS)
Calcium
Motor neuron
Mitochondria
Proteasome
SOD1
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000283

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http://www.sciencedirect.com/science/article/pii/S0969996111000283

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