The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system

<p>Abstract</p> <p>Background</p> <p>Previous studies have demonstrated that intrathecal administration of the substance P amino-terminal metabolite substance P<sub>1-7 </sub>(SP<sub>1-7</sub>) and its C-terminal amidated congener induced antihyp...

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Bibliographic Details
Main Authors: Ohsawa Masahiro, Carlsson Anna, Asato Megumi, Koizumi Takayuki, Nakanishi Yuki, Fransson Rebecca, Sandström Anja, Hallberg Mathias, Nyberg Fred, Kamei Junzo
Format: Article
Language:English
Published: SAGE Publishing 2011-10-01
Series:Molecular Pain
Subjects:
Allodynia
Antinociception
Diabetes
Hyperalgesia
Opioid receptors
Phe-Phe amide
σ<sub>1 </sub>receptor
Substance P<sub>1-7</sub>
Online Access:http://www.molecularpain.com/content/7/1/85

Internet

http://www.molecularpain.com/content/7/1/85

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