Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells

Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells

Perinatal inflammatory stress is strongly associated with adverse pulmonary outcomes after preterm birth. Antenatal infections are an essential perinatal stress factor and contribute to preterm delivery, induction of lung inflammation and injury, pre-disposing preterm infants to bronchopulmonary dys...

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Bibliographic Details
Main Authors: Helene Widowski, Niki L. Reynaert, Daan R. M. G. Ophelders, Matthias C. Hütten, Peter G. J. Nikkels, Carmen A. H. Severens-Rijvers, Jack P. M. Cleutjens, Matthew W. Kemp, John P. Newnham, Masatoshi Saito, Haruo Usuda, Matthew S. Payne, Alan H. Jobe, Boris W. Kramer, Tammo Delhaas, Tim G. A. M. Wolfs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Medicine
Subjects:
polymicrobial infection
vascular disturbances
adverse pulmonary outcomes
endogenous pulmonary stem cells
bronchopulmonary dysplasia
preterm birth
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.614239/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.614239/full

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