Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions

Pluripotent stem cell-derived CAR-macrophage cells with antigen-dependent anti-cancer cell functions

Abstract The Chimera antigen receptor (CAR)-T cell therapy has gained great success in the clinic. However, there are still major challenges for its wider applications in a variety of cancer types including lack of effectiveness due to the highly complex tumor microenvironment, and the forbiddingly...

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Bibliographic Details
Main Authors: Li Zhang, Lin Tian, Xiaoyang Dai, Hua Yu, Jiajia Wang, Anhua Lei, Mengmeng Zhu, Jianpo Xu, Wei Zhao, Yuqing Zhu, Zhen Sun, Hao Zhang, Yongxian Hu, Yanlin Wang, Yuming Xu, George M. Church, He Huang, Qinjie Weng, Jin Zhang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Journal of Hematology & Oncology
Subjects:
Chimera antigen receptor (CAR)
Induced pluripotent stem cells (iPSC)-derived macrophage cells (iMac)
Antigen-dependent activation
Anti-cancer cell functions
Online Access:http://link.springer.com/article/10.1186/s13045-020-00983-2

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http://link.springer.com/article/10.1186/s13045-020-00983-2

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