Insights From Computational Modeling Into the Contribution of Mechano-Calcium Feedback on the Cardiac End-Systolic Force-Length Relationship

Insights From Computational Modeling Into the Contribution of Mechano-Calcium Feedback on the Cardiac End-Systolic Force-Length Relationship

In experimental studies on cardiac tissue, the end-systolic force-length relation (ESFLR) has been shown to depend on the mode of contraction: isometric or isotonic. The isometric ESFLR is derived from isometric contractions spanning a range of muscle lengths while the isotonic ESFLR is derived from...

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Bibliographic Details
Main Authors: Megan E. Guidry, David P. Nickerson, Edmund J. Crampin, Martyn P. Nash, Denis S. Loiselle, Kenneth Tran
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
end-systolic force-length relations
cardiac calcium transient
thin filament activation
calcium-troponin binding affinity
cardiac excitation-contraction model
mechano-calcium feedback
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00587/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00587/full

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