Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

A series of sp2-iminosugar glycomimetics differing in the reducing or nonreducing character, the configurational pattern (d-gluco or l-ido), the architecture of the glycone skeleton, and the nature of the nonglycone substituent has been synthesized and assayed for their inhibition properties towards...

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Bibliographic Details
Main Authors: Teresa Mena-Barragán, M. Isabel García-Moreno, Alen Sevšek, Tetsuya Okazaki, Eiji Nanba, Katsumi Higaki, Nathaniel I. Martin, Roland J. Pieters, José M. García Fernández, Carmen Ortiz Mellet
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Molecules
Subjects:
sp2-Iminosugars
deoxynojirimycin
glycosidase inhibitors
glucocerebrosidase
chaperones
Gaucher disease
Online Access:http://www.mdpi.com/1420-3049/23/4/927

Internet

http://www.mdpi.com/1420-3049/23/4/927

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