Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology

Reduced Abundance and Subverted Functions of Proteins in Prion-Like Diseases: Gained Functions Fascinate but Lost Functions Affect Aetiology

Prions have served as pathfinders that reveal many aspects of proteostasis in neurons. The recent realization that several prominent neurodegenerative diseases spread via a prion-like mechanism illuminates new possibilities for diagnostics and therapeutics. Thus, key proteins in Alzheimer Disease an...

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Bibliographic Details
Main Authors: W. Ted Allison, Michèle G. DuVal, Kim Nguyen-Phuoc, Patricia L. A. Leighton
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:International Journal of Molecular Sciences
Subjects:
protein homeostasis
prion-like disease
amyotrophic lateral sclerosis
functional amyloid
scrapie
premelanosome protein (PMEL17)
strains
SOD1
Online Access:https://www.mdpi.com/1422-0067/18/10/2223

Internet

https://www.mdpi.com/1422-0067/18/10/2223

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