Knocking out the Vitamin D Receptor Enhances Malignancy and Decreases Responsiveness to Vitamin D3 Hydroxyderivatives in Human Melanoma Cells

Knocking out the Vitamin D Receptor Enhances Malignancy and Decreases Responsiveness to Vitamin D3 Hydroxyderivatives in Human Melanoma Cells

Vitamin D3 is not only involved in calcium and phosphate metabolism in humans, but it can also affect proliferation and differentiation of normal and cancer cells, including melanoma. The mechanism of the anti-cancer action of vitamin D3 is not fully understood. The nuclear vitamin D receptor (VDR)...

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Bibliographic Details
Main Authors: Ewa Podgorska, Tae-Kang Kim, Zorica Janjetovic, Krystyna Urbanska, Robert C. Tuckey, Sejong Bae, Andrzej T. Slominski
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
melanoma
vitamin D
vitamin D receptor
active forms of vitamin D
malignancy
Online Access:https://www.mdpi.com/2072-6694/13/13/3111

Internet

https://www.mdpi.com/2072-6694/13/13/3111

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