Efficient estimation of the robustness region of biological models with oscillatory behavior.

Robustness is an essential feature of biological systems, and any mathematical model that describes such a system should reflect this feature. Especially, persistence of oscillatory behavior is an important issue. A benchmark model for this phenomenon is the Laub-Loomis model, a nonlinear model for...

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Bibliographic Details
Main Authors: Mochamad Apri, Jaap Molenaar, Maarten de Gee, George van Voorn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2848571?pdf=render