Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans

Modifier locus mapping of a transgenic F2 mouse population identifies CCDC115 as a novel aggressive prostate cancer modifier gene in humans

Abstract Background It is well known that development of prostate cancer (PC) can be attributed to somatic mutations of the genome, acquired within proto-oncogenes or tumor-suppressor genes. What is less well understood is how germline variation contributes to disease aggressiveness in PC patients....

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Bibliographic Details
Main Authors: Jean M. Winter, Natasha L. Curry, Derek M. Gildea, Kendra A. Williams, Minnkyong Lee, Ying Hu, Nigel P. S. Crawford
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Genomics
Subjects:
Prostate cancer
Germline variation
Quantitative trait loci
CCDC115
DNAJC10
RNF149
Online Access:http://link.springer.com/article/10.1186/s12864-018-4827-2

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http://link.springer.com/article/10.1186/s12864-018-4827-2

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