Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells.

Anti-tumor effect against human cancer xenografts by a fully human monoclonal antibody to a variant 8-epitope of CD44R1 expressed on cancer stem cells.

BACKGROUND: CD44 is a major cellular receptor for hyaluronic acids. The stem structure of CD44 encoded by ten normal exons can be enlarged by ten variant exons (v1-v10) by alternative splicing. We have succeeded in preparing MV5 fully human IgM and its class-switched GV5 IgG monoclonal antibody (mAb...

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Bibliographic Details
Main Authors: Kazue Masuko, Shogo Okazaki, Mayumi Satoh, Goh Tanaka, Tatsuya Ikeda, Ryota Torii, Eri Ueda, Takashi Nakano, Masaaki Danbayashi, Tomoyo Tsuruoka, Yoshiya Ohno, Hideki Yagi, Noritsugu Yabe, Hideaki Yoshida, Tomoyuki Tahara, Shiro Kataoka, Taichi Oshino, Takayuki Shindo, Shin-ichiro Niwa, Takatsugu Ishimoto, Hideo Baba, Yoshiyuki Hashimoto, Hideyuki Saya, Takashi Masuko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3260170?pdf=render

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http://europepmc.org/articles/PMC3260170?pdf=render

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