VIPhyb, an antagonist of vasoactive intestinal peptide receptor, enhances cellular antiviral immunity in murine cytomegalovirus infected mice.

VIPhyb, an antagonist of vasoactive intestinal peptide receptor, enhances cellular antiviral immunity in murine cytomegalovirus infected mice.

Vasoactive intestinal peptide (VIP) is a neuropeptide hormone that suppresses Th1-mediated cellular immunity. We previously reported that VIP-knockout (VIP-KO) mice have enhanced cellular immune responses and increased survival following murine cytomegalovirus (mCMV) infection in C57BL/6 mice. In th...

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Bibliographic Details
Main Authors: Jian-Ming Li, Kasia A Darlak, Lauren Southerland, Mohammad S Hossain, David L Jaye, Cassandra D Josephson, Hilary Rosenthal, Edmund K Waller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3664580?pdf=render

Internet

http://europepmc.org/articles/PMC3664580?pdf=render

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