Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes

Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes

Osteoarthritis (OA) is a degenerative joint disease that not only causes cartilage loss but also structural damage in all joint tissues. Joints are innervated by alpha-calcitonin gene-related peptide (αCGRP) and substance P (SP)-positive sensory nerve fibers. Alteration of sensory joint innervation...

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Bibliographic Details
Main Authors: Sabine Stöckl, Annett Eitner, Richard J. Bauer, Matthias König, Brian Johnstone, Susanne Grässel
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
osteoarthritis
SP
αCGRP
sensory nervous system
chondrocyte metabolism
ERK
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.722884/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.722884/full

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