Immune Modulatory Cell Therapy for Hemophilia B Based on CD20-Targeted Lentiviral Gene Transfer to Primary B Cells

Immune Modulatory Cell Therapy for Hemophilia B Based on CD20-Targeted Lentiviral Gene Transfer to Primary B Cells

Gene-modified B cells expressing immunoglobulin G (IgG) fusion proteins have been shown to induce tolerance in several autoimmune and other disease models. However, lack of a vector suitable for gene transfer to human B cells has been an obstacle for translation of this approach. To overcome this hu...

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Bibliographic Details
Main Authors: Xiaomei Wang, Roland W. Herzog, Barry J. Byrne, Sandeep R.P. Kumar, Qi Zhou, Christian J. Buchholz, Moanaro Biswas
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
hemophilia B
CD20
SCFV
lentivirus
gene transfer
measles virus
psuedotype
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300505

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http://www.sciencedirect.com/science/article/pii/S2329050117300505

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