Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy. One approach to enhancing macrophage cholest...

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Bibliographic Details
Main Authors: Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Journal of Lipid Research
Subjects:
ATP-binding cassette transporter A1
atherosclerosis
macrophages
cholesterol efflux
ATP-binding cassette transporter G1
scavenger receptor class B type I
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312372

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http://www.sciencedirect.com/science/article/pii/S0022227520312372

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