Elucidating the Antimycobacterial Mechanism of Action of Ciprofloxacin Using Metabolomics

Elucidating the Antimycobacterial Mechanism of Action of Ciprofloxacin Using Metabolomics

In the interest of developing more effective and safer anti-tuberculosis drugs, we used a GCxGC-TOF-MS metabolomics research approach to investigate and compare the metabolic profiles of <i>Mtb</i> in the presence and absence of ciprofloxacin. The metabolites that best describe the diffe...

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Bibliographic Details
Main Authors: Kirsten E. Knoll, Zander Lindeque, Adetomiwa A. Adeniji, Carel B. Oosthuizen, Namrita Lall, Du Toit Loots
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Microorganisms
Subjects:
fluoroquinolones
ciprofloxacin
untargeted metabolomics
<i>Mycobacterium tuberculosis</i>
tuberculosis
GCxGC-TOFMS
Online Access:https://www.mdpi.com/2076-2607/9/6/1158

Internet

https://www.mdpi.com/2076-2607/9/6/1158

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