Implementation of homology based and non-homology based computational methods for the identification and annotation of orphan enzymes: using Mycobacterium tuberculosis H37Rv as a case study

Implementation of homology based and non-homology based computational methods for the identification and annotation of orphan enzymes: using Mycobacterium tuberculosis H37Rv as a case study

Abstract Background Homology based methods are one of the most important and widely used approaches for functional annotation of high-throughput microbial genome data. A major limitation of these methods is the absence of well-characterized sequences for certain functions. The non-homology methods b...

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Bibliographic Details
Main Authors: Swati Sinha, Andrew M. Lynn, Dhwani K. Desai
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Bioinformatics
Subjects:
Homology based method
Non-homology based methods
Local hole
Global hole
Chokepoints
Missing enzyme
Online Access:http://link.springer.com/article/10.1186/s12859-020-03794-x

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http://link.springer.com/article/10.1186/s12859-020-03794-x

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