Retrotransposon silencing by DNA methylation can drive mammalian genomic imprinting.

Among mammals, only eutherians and marsupials are viviparous and have genomic imprinting that leads to parent-of-origin-specific differential gene expression. We used comparative analysis to investigate the origin of genomic imprinting in mammals. PEG10 (paternally expressed 10) is a retrotransposon...

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Main Authors: Shunsuke Suzuki, Ryuichi Ono, Takanori Narita, Andrew J Pask, Geoffrey Shaw, Changshan Wang, Takashi Kohda, Amber E Alsop, Jennifer A Marshall Graves, Yuji Kohara, Fumitoshi Ishino, Marilyn B Renfree, Tomoko Kaneko-Ishino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1851980?pdf=render