Genetic Variants and Somatic Alterations Associated with MITF-E318K Germline Mutation in Melanoma Patients

Genetic Variants and Somatic Alterations Associated with MITF-E318K Germline Mutation in Melanoma Patients

The MITF-E318K variant has been implicated in genetic predisposition to cutaneous melanoma. We addressed the occurrence of MITF-E318K and its association with germline status of CDKN2A and MC1R genes in a hospital-based series of 248 melanoma patients including cohorts of multiple, familial, pediatr...

Full description

Bibliographic Details
Main Authors: Elisabetta Vergani, Simona Frigerio, Matteo Dugo, Andrea Devecchi, Erika Feltrin, Loris De Cecco, Viviana Vallacchi, Mara Cossa, Lorenza Di Guardo, Siranoush Manoukian, Bernard Peissel, Andrea Ferrari, Gianfrancesco Gallino, Andrea Maurichi, Licia Rivoltini, Marialuisa Sensi, Monica Rodolfo
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Genes
Subjects:
cutaneous melanoma
MITF gene
MITF-E318K variant
germline mutations
somatic mutations
copy number alterations
Online Access:https://www.mdpi.com/2073-4425/12/9/1440

Internet

https://www.mdpi.com/2073-4425/12/9/1440

Similar Items