A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in Caenorhabditis elegans.

Prolonged alcohol consumption in humans followed by abstinence precipitates a withdrawal syndrome consisting of anxiety, agitation and in severe cases, seizures. Withdrawal is relieved by a low dose of alcohol, a negative reinforcement that contributes to alcohol dependency. This phenomenon of '...

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Bibliographic Details
Main Authors: Philippa Mitchell, Richard Mould, James Dillon, Steven Glautier, Ioannis Andrianakis, Christopher James, Amanda Pugh, Lindy Holden-Dye, Vincent O'Connor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2862703?pdf=render