Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells.

Identification of anti-malarial compounds as novel antagonists to chemokine receptor CXCR4 in pancreatic cancer cells.

Despite recent advances in targeted therapies, patients with pancreatic adenocarcinoma continue to have poor survival highlighting the urgency to identify novel therapeutic targets. Our previous investigations have implicated chemokine receptor CXCR4 and its selective ligand CXCL12 in the pathogenes...

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Bibliographic Details
Main Authors: Joseph Kim, M L Richard Yip, Xiaoming Shen, Hubert Li, Li-Yu Charlie Hsin, Samuel Labarge, Eileen L Heinrich, Wendy Lee, Jianming Lu, Nagarajan Vaidehi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3272047?pdf=render

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http://europepmc.org/articles/PMC3272047?pdf=render

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